BIORESORBABLE SCAFFOLDS: CONTEMPORARY STATUS AND FUTURE DIRECTIONS



Collapse of a marine mammal species driven by human impacts.

Understanding historical roles of species in ecosystems can be crucial for assessing long term human impacts on environments, providing context for management or restoration objectives, and making conservation evaluations of species status.In most cases limited historical abundance data impedes quantitative investigations, but harvested species may

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Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods [version 1; peer review: 2 approved]

Background: Heat shock protein (Hsp90KDa) is a molecular chaperone involved in the process of cellular oncogenesis, hence its importance as a therapeutic target in clinical trials.Geldanamycin is an inhibitor of Hsp90 chaperone activity, which binds to the ATP binding site in the N-terminal domain of Hsp90.However, geldanamycin has shown hepatotoxi

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